NDLI: Glycine modulation of NMDA-evoked release of [3H]acetylcholine and [3H]dopamine from rat striatal slices

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Glycine modulation of NMDA-evoked release of [3H]acetylcholine and [3H]dopamine from rat striatal slices

Content Provider	Semantic Scholar
Author	Ransom, Richard W. Deschenes, N. L.
Copyright Year	1989
Abstract	Superfused slices of rat striatum were used to investigate whether N-methyl-D-aspartate (NMDA) receptors mediating [3H]acetylcholine (ACh) and [3H]dopamine (DA) release are modulated by glycine. Kynurenic acid, a compound possessing antagonist activity at the receptor's glycine modulatory site, dose-dependently blocked NMDA release of both transmitters. The inhibition was reversed by glycine, D-serine, D-alanine, D-cysteine, L-serine and L-alanine. The relative potencies of these amino acids was in agreement with their previously reported abilities to inhibit strychnine-insensitive [3H]glycine binding and enhance [3H]MK-801 binding to the NMDA receptor complex. These data indicate that glycine modulatory sites are linked to NMDA receptors involved in striatal [3H]ACh and [3H]DA release.
Starting Page	323
Ending Page	328
Page Count	6
File Format	PDF HTM / HTML
DOI	10.1016/0304-3940(89)90399-6
PubMed reference number	2541381
Journal	Medline
Volume Number	96
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/0304394089903996
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/0304394089903996?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/0304-3940%2889%2990399-6
Journal	Neuroscience Letters
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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