Hyperbaric oxygen therapy in acute ischemic stroke: results of the Hyperbaric Oxygen in Acute Ischemic Stroke Trial Pilot Study.

Content Provider	Semantic Scholar
Author	Rusyniak, Daniel E. May, Jason D. Kao, Louise Welch, Julie L. Alonso, Robert J.
Copyright Year	2003
Abstract	BACKGROUND AND PURPOSE Hyperbaric oxygen therapy (HBO) has promise as a treatment for acute stroke. This study was conducted to evaluate the efficacy, safety, and feasibility of using HBO in acute ischemic stroke. METHODS We conducted a randomized, prospective, double-blind, sham-controlled pilot study of 33 patients presenting with acute ischemic stroke who did not receive thrombolytics over a 24-month period. Patients were randomized to treatment for 60 minutes in a monoplace hyperbaric chamber pressurized with 100% O2 to 2.5-atm absolute (ATA) in the HBO group or 1.14 ATA in the sham group. Primary outcomes measured included percentage of patients with improvement at 24 hours (National Institutes of Health Stroke Scale [NIHSS]) and 90 days (NIHSS, Barthel Index, modified Rankin Scale, Glasgow Outcome Scale). Secondary measurements included complications of treatment and mortality at 90 days. RESULTS Baseline demographics were similar in both groups. There were no differences between the groups at 24 hours (P=0.44). At 3 months, however, a larger percentage of the sham patients had a good outcome defined by their stroke scores compared with the HBO group (NIHSS, 80% versus 31.3%; P=0.04; Barthel Index, 81.8% versus 50%; P=0.12; modified Rankin Scale, 81.8% versus 31.3%; P=0.02; Glasgow Outcome Scale, 90.9% versus 37.5%; P=0.01) with loss of statistical significance in a intent-to-treat analysis. CONCLUSIONS Although our HBO protocol appears feasible and safe, it does not appear to be beneficial and may be harmful in patients with acute ischemic stroke.
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Alternate Webpage(s)	http://www.sld.cu/galerias/pdf/sitios/rehabilitacion-fis/ohb_y_stroke.pdf
Alternate Webpage(s)	http://stroke.ahajournals.org/content/34/2/571.full.pdf
Alternate Webpage(s)	https://pdfs.semanticscholar.org/aac6/59739dad11d010cf83c93691d715743a0f49.pdf
Alternate Webpage(s)	http://hyperbarictherapycenterofrome.com/articles/HBO_Stroke_Study.pdf
Alternate Webpage(s)	http://stroke.ahajournals.org/content/strokeaha/34/2/571.full.pdf
Alternate Webpage(s)	http://stroke.ahajournals.org/content/strokeaha/34/2/571.full.pdf?download=true
PubMed reference number	12574578v1
Volume Number	34
Issue Number	2
Journal	Stroke
Language	English
Access Restriction	Open
Subject Keyword	Acute inflammatory demyelinating polyneuropathy CHAMBER, HYPERBARIC Cerebral Infarction Cerebrovascular accident Demography Eighty Fibrinolytic Agents Hyperbaric Oxygen (substance) Hyperbaric oxygenation therapy Large Leukemia, Myelocytic, Acute Neoplasm Metastasis Oxygen Therapy Care P-Value Patients pediatric acute myeloblastic leukemia
Content Type	Text
Resource Type	Article