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DNA alkylation promoted by an electron-rich quinone methide intermediate
| Content Provider | Semantic Scholar |
|---|---|
| Author | Huang, Chengyun Rokita, Steven E. |
| Copyright Year | 2015 |
| Abstract | Biological application of conjugates derived from oligonucleotides and quinone methides have previously been limited by the slow exchange of their covalent self-adducts and subsequent alkylation of target nucleic acids. To enhance the rates of these processes, a new quinone methide precursor with an electron donating substituent has been prepared. Additionally, this substituent has been placed para to the nascent exo-methylene group of the quinone methide for maximum effect. A conjugate made from this precursor and a 5'-aminohexyloligonucleotide accelerates formation of its reversible self-adduct and alkylation of its complementary DNA as predicted from prior model studies. |
| Starting Page | 213 |
| Ending Page | 221 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| DOI | 10.1007/s11705-015-1541-3 |
| Volume Number | 10 |
| Alternate Webpage(s) | http://academic.hep.com.cn/fileup/2095-0179/SUPPL/20151120094500.pdf |
| Alternate Webpage(s) | https://doi.org/10.1007/s11705-015-1541-3 |
| Journal | Frontiers of Chemical Science and Engineering |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
