NDLI: Anodal transcranial direct current stimulation over right dorsolateral prefrontal cortex alters decision making during approach-avoidance conflict

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Anodal transcranial direct current stimulation over right dorsolateral prefrontal cortex alters decision making during approach-avoidance conflict

Content Provider	Semantic Scholar
Author	Chrysikou, Evangelia G. Gorey, Claire Aupperle, Robin L.
Copyright Year	2017
Abstract	Approach-avoidance conflict (AAC) refers to situations associated with both rewarding and threatening outcomes. The AAC task was developed to measure AAC decision-making. Approach behavior during this task has been linked to self-reported anxiety sensitivity and has elicited anterior cingulate, insula, caudate and right dorsolateral prefrontal cortex (dlPFC) activity, with right lateral PFC tracking the extent of approach behavior. Guided by these results, we used excitatory transcranial direct current stimulation (tDCS) to demonstrate the causal involvement of right dlPFC in AAC decision-making. Participants received anodal tDCS at 1.5mA over either left or right dlPFC or sham stimulation, while performing the AAC task and a control short-term memory task. Analyses of variance (ANOVA) revealed that for individuals with high anxiety sensitivity excitatory right (but not left or sham) dlPFC stimulation elicited measurable decreases in approach behavior during conflict. Excitatory left (but not right or sham) dlPFC simulation improved performance on the control task. These results support a possible asymmetry between the contributions of right and left dlPFC to AAC resolution during emotional decision-making. Increased activity in right dlPFC may contribute to anxiety-related symptoms and, as such, serve as a neurobehavioral target of anxiolytic treatments aiming to decrease avoidance behavior.
Starting Page	468
Ending Page	475
Page Count	8
File Format	PDF HTM / HTML
DOI	10.1093/scan/nsw140
PubMed reference number	27694531
Journal	Medline
Volume Number	12
Alternate Webpage(s)	https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/69/61/nsw140.PMC5390716.pdf
Alternate Webpage(s)	https://doi.org/10.1093/scan%2Fnsw140
Journal	Social cognitive and affective neuroscience
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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