Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Recurrent Epithelial Ovarian Cancer , the First Egyptian Experience

Content Provider	Semantic Scholar
Author	Gareer, Wy Hwy, Gareer Alaadin, Hussein Alghazali
Copyright Year	2017
Abstract	Background: For 3 decades cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) has been introduced as an effective technique in treating peritoneal carcinomatosis (PC) from different primaries with promising results in selected patients .The Aim of this study is to evaluate the early and late outcomes of CRS and HIPEC in management of recurrent epithelial ovarian cancer (REOC) with PC as the first Egyptian experience. Methods: In the period between September 2009 and December 2013 we treated 42 patients with PC from REOC with CRS and HIPEC using the closed abdominal technique. The perioperative complications, toxicity grade, overall survival (OS), disease free survival (DFS), mortality rates, and effects of peritoneal carcinomatosis index (PCI), completeness of cytoreduction, patient age and tumor type and grade on survival had been reported and analyzed. Results: The mean age was 51.2±7.9 (range 34-64 years). PCI was <16 in 47.7%; 16-20 in 45.2% and >20 in 7.1%). Postoperative mortality rate was 2.38%. The mean disease free survival (DFS) was 11.9±9.75 (median 9.0; range 0-51 months), while the cumulative overall survival (OS) was 73.6% at 18 months, and 55.5% at 2 years.PCI found to be a significant risk factor when we compared PCI < 16 with PCI > 16 (p = 0.001. Completeness of cytoreduction was associated with higher OS. Age > 60 years was associated with a significantly lower OS (p = 0.003). Serous papillary tumors were associated with better survival. Low tumor grade was associated with longer OS survival with no significant difference (0. 628). Conclusion: CRS and HIPEC along with the extent of the disease and the extent of cytoreduction play a crucial role in the survival of patients with REOC, and as a technique it is feasible with acceptable morbidity, mortality (2.38%) and toxicity when good patients’ selection and systematic intra operative assessment are strictly applied.
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Language	English
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Subject Keyword	Adverse reaction to drug Borderline Ovarian Serous Tumor Craniosynostosis Disease-Free Survival Egyptian language Epithelial ovarian cancer Fever Hyperthermic Intraperitoneal Chemotherapy Morbidity - disease rate Mortality Vital Statistics Operating system Overall Survival Patients Peritoneal Cancer Index Peritoneal Carcinomatosis Pupillary distance Recurrent neural network Toxicity Grade ovarian neoplasm papillary neoplasms recurrent childhood brain stem glioma recurrent ovarian epithelial cancer
Content Type	Text
Resource Type	Article