NDLI: How Do Donor-Recipient CMV Serostatus and Post-Hematopoietic Stem Cell Transplantation CMV Reactivation Affect Outcomes in Acute Leukemia Patients?

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How Do Donor-Recipient CMV Serostatus and Post-Hematopoietic Stem Cell Transplantation CMV Reactivation Affect Outcomes in Acute Leukemia Patients?

Content Provider	Semantic Scholar
Author	Vaezi, Mohammad Kasaeian, Amir Souri, Maryam Soufiyan, Faeze Boosjin, Amir Shokri Setarehdan, Seyed Amin Alimoghaddam, Kamran Ghavamzadeh, Ardeshir
Copyright Year	2017
Abstract	Background: This study evaluated CMV serostatus in donors and recipients of hematopoietic stem cell transplantation (HSCT) and its effects on CMV reactivation of patients and all aspects of CMV on HSCT outcomes. Materialsand Methods: Seven hundred and five adult acute leukemia patients (AML=408 and AML=297) who had undergone HSCT were included in this retrospective study. We categorized donor-recipient pairs in three risk groups: positive donors (D+) were studied as high-risk group, including either R+ or R-(n=485), R-D- as low-risk group (n=32) and R+D- as intermediate group (n=15). Results: There was no statistically difference in CMV reactivation among these risk groups (P=0.14).CMV infection rate was lower in R+D+ than R+D-(p=0.050). Multivariate analysis showed that patients developing CMV infection had lower overall survival (p=0.04, HR: 1.43, CI=1.00- 2.05) and higher non- relapse mortality (P=0.01, HR: 1.62, CI=1.11-2.38). Relapse rate did not change in CMV reactivated patients (P=0.94). Conclusion: The results of the study indicated that asCMV reactivation occurred more in R+D- patients compared to R+D+ ones, and was associated with inferior OS and higher NRM it could be suggested that in contrast to general belief, if the recipient is seropositive , seropositive donor is preferred to a seronegative one.
Starting Page	199
Ending Page	208
Page Count	10
File Format	PDF HTM / HTML
PubMed reference number	28989586
Journal	Medline
Volume Number	11
Alternate Webpage(s)	http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/download/617/559
Journal	International journal of hematology-oncology and stem cell research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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