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Histidyl-proline diketopiperazine (His-Pro DKP) immunoreactivity is present in the glucagon-containing cells of the human fetal pancreas.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Leduque, Patrick Jackson, Ivor M. D. Kervran, Alain Aratan-Spire, Sonia Czernichow, P. Dubois, P. M. |
| Copyright Year | 1987 |
| Abstract | Histidyl-proline diketopiperazine (His-Pro DKP) cells in the pancreas of human fetuses aged between 12 and 19 wk were localized by the indirect antibody-enzyme method on semithin sections. To study their fine structure, two techniques were used: a superimposition technique consisting of comparison of the same cells in semithin and electron microscopic preparations, and an immunocytochemical technique on ultrathin sections using the unlabeled antibody peroxidase-antiperoxidase method. Our results show that (a) the same cells are positive for both His-Pro DKP and glucagon/glicentin, (b) His-Pro DKP immunoreactive cells possess extremely electron-opaque secretory granules, implying that these cells correspond to the A cells, and (c) His-Pro DKP immunoreactivity is found over the secretory granules. We hypothesize that the two peptides His-Pro DKP and thyrotropin-releasing hormone (TRH) have independent origins, since TRH is found in the B cells. |
| File Format | PDF HTM / HTML |
| DOI | 10.1172/JCI112897 |
| PubMed reference number | 3102558 |
| Journal | Medline |
| Volume Number | 79 |
| Issue Number | 3 |
| Alternate Webpage(s) | http://dm5migu4zj3pb.cloudfront.net/manuscripts/112000/112897/JCI87112897.pdf |
| Alternate Webpage(s) | http://www.jci.org/articles/view/112897/version/1/pdf/render |
| Alternate Webpage(s) | https://doi.org/10.1172/JCI112897 |
| Journal | The Journal of clinical investigation |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
