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Differences in the Levels of Interleukin-1β (IL-1β) and Interleukin-1 Receptor Antagonist (IL-1ra) in Children with Status Epilepticus and Febrile Seizure
| Content Provider | Semantic Scholar |
|---|---|
| Author | Shofiyah, Fita Muid, Masdar Sujuti, Hidayat |
| Copyright Year | 2017 |
| Abstract | Proinflammatory cytokines are elevated in status epilepticus and febrile seizure and associated with tissue damage. This study aimed to investigate the differences in interleukin 1 beta (IL-1β) and interleukin 1 receptor agonist (IL-1ra) levels in status epilepticus as compared with febrile seizure and febrile. This cross-sectional study was designed to include 45 subjects divided equally into three groups (status epilepticus, febrile seizure, and febrile). Both IL-1β and IL-1ra were measured by using an ELISA method. Results showed that IL-1β levels were significantly higher in the status epilepticus group as compared with the febrile seizure and febrile groups (p < 0.05). IL-1ra levels in the status epilepticus group were significantly lower compared with the febrile seizure group (p = 0.04). Consistently, the IL-1β/IL-1ra ratio in the status epilepticus group was significantly higher as compared with the febrile seizure group (p = 0.01). We concluded that IL-1β and the IL-1β/IL-1ra ratio were significantly higher in status epilepticus. IL-1ra levels were significantly higher in the febrile seizure group. |
| Starting Page | 213 |
| Ending Page | 217 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.11594/jtls.07.03.05 |
| Volume Number | 7 |
| Alternate Webpage(s) | https://jtrolis.ub.ac.id/index.php/jtrolis/article/download/722/pdf |
| Alternate Webpage(s) | http://www.jtrolis.ub.ac.id/index.php/jtrolis/article/download/722/pdf |
| Alternate Webpage(s) | https://doi.org/10.11594/jtls.07.03.05 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
