Genomic mutation-driven metastatic breast cancer therapy: a single center experience

Content Provider	Semantic Scholar
Author	Yuan, Yuan Yost, Susan E. Yuan, Y. Solomon, Nicola M. Mambetsariev, Isa Pal, Sumanta Kumar Frankel, Paul Henry Salgia, Ravi Neuhausen, Susan L. Mortimer, Joanne
Copyright Year	2017
Abstract	BACKGROUND Next-Generation Sequencing (NGS) has made genomic mutation-driven therapy feasible for metastatic breast cancer (MBC) patients. We frequently submit tumor tissue from MBC patients for targeted NGS of tumor using the Illumina HiSeq 2000 platform (FoundationOne®, Foundation Medicine, MA). Herein, we report the results and clinical impact of this test in MBC patients. PATIENTS AND METHODS We identified patients with MBC treated at City of Hope from January 2014 to May 2016 who underwent NGS. Patients' clinical characteristics, response to treatment (clinical assessment of tumor regression), and genomic mutation profiles were reviewed. RESULTS Forty-four patients with MBC underwent NGS: 24 triple negative breast cancer, 16 estrogen receptor positive, and 4 human epidermal growth factor receptor 2 positive patients. Twenty-three patients received more than three lines of chemotherapy prior to NGS. Actionable mutations (potentially responsive to targeted therapies that are on the market or in registered clinical trials) were identified in almost all patients (42/44; 95%) and over half of these 42 patients with actionable mutations (23/42; 55%) initiated mutation-driven targeted therapies. Of these 23 patients, 16/23 (70%) had assessable responses, and 7/23 (30%) were not assessable for response due to short exposure (<2 weeks) or hospice transition. The remaining 19/42 (45%) patients did not initiate targeted therapy. CONCLUSION NGS can identify effective targeted therapy options for MBC patients based on actionable mutations that were not previously offered based on pathology type. NGS should be performed early in patients with good performance status and preferably in clinical settings where genomic mutation-driven therapeutic trials are available.
Starting Page	26414
Ending Page	26423
Page Count	10
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.oncotarget.com/index.php?journal=oncotarget&op=download&page=article&path%5B%5D=14476&path%5B%5D=46171
PubMed reference number	28061482
Alternate Webpage(s)	https://doi.org/10.18632/oncotarget.14476
DOI	10.18632/oncotarget.14476
Journal	Oncotarget
Volume Number	8
Language	English
Access Restriction	Open
Subject Keyword	Carcinoma breast stage IV Estrogens Growth Factor Receptors Mammary Neoplasms Mutation Patients Registration Status Epilepticus Targeted Therapy Therapeutic procedure Triple Negative Breast Neoplasms Unevaluable mecarzole tumor tissue
Content Type	Text
Resource Type	Article