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A Rapid Increase in cAMP in Response to 20-Hydroxyecdysone in the Anterior Silk Glands of the Silkworm, Bombyx mori
| Content Provider | Semantic Scholar |
|---|---|
| Author | Elmogy, Mohamed Terashima, Jun Iga, Masatoshi Iwami, Masafumi Sakurai, Sho |
| Copyright Year | 2006 |
| Abstract | Abstract In the anterior silk glands (ASGs) of the silkworm, Bombyx mori, intracellular cAMP increases transiently to a very high level shortly after the hemolymph ecdysteroid peak in the prepupal period. In cultured ASGs obtained on the day of gut-purge, cAMP levels were increased by 20-hydroxy-ecdysone (20E), and this increase was enhanced by an inhibitor of phosphodiesterase, but was not affected by α-amanitin, indicating the 20E action may not be mediated via gene expression. The increase in cAMP occurred within 30 seconds of exposure to a physiological concentration of 20E (1 μM), and also by ponasterone A. Our findings indicate a nongenomic action of ecdysteroids in insects, which may be an additional mechanism by which this steroid hormone induces acute responses in tissues and cells. |
| Starting Page | 715 |
| Ending Page | 719 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.2108/zsj.23.715 |
| PubMed reference number | 16971790 |
| Journal | Medline |
| Volume Number | 23 |
| Alternate Webpage(s) | http://dspace.lib.kanazawa-u.ac.jp/dspace/bitstream/2297/28994/1/SC-PR-SAKURAI-S-715.pdf |
| Alternate Webpage(s) | https://doi.org/10.2108/zsj.23.715 |
| Journal | Zoological science |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
