NDLI: Large porous particles for pulmonary drug delivery.

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Large porous particles for pulmonary drug delivery.

Content Provider	Semantic Scholar
Author	Edwards, David A. Hanes, Justin Caponetti, Giovanni Hrkach, J. S. Ben-Jebria, Abdellaziz Eskew, Mary Lou Mintzes, Jeffrey D. Deaver, David Lotan, Noah Langer, Robert
Copyright Year	1997
Abstract	A new type of inhalation aerosol, characterized by particles of small mass density and large size, permitted the highly efficient delivery of inhaled therapeutics into the systemic circulation. Particles with mass densities less than 0.4 gram per cubic centimeter and mean diameters exceeding 5 micrometers were inspired deep into the lungs and escaped the lungs' natural clearance mechanisms until the inhaled particles delivered their therapeutic payload. Inhalation of large porous insulin particles resulted in elevated systemic levels of insulin and suppressed systemic glucose levels for 96 hours, whereas small nonporous insulin particles had this effect for only 4 hours. High systemic bioavailability of testosterone was also achieved by inhalation delivery of porous particles with a mean diameter (20 micrometers) approximately 10 times that of conventional inhaled therapeutic particles.
Starting Page	17
Ending Page	23
Page Count	7
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://signallake.com/innovation/EdwardsScience062097.pdf
Alternate Webpage(s)	http://www.signallake.com/innovation/EdwardsScience062097.pdf
Alternate Webpage(s)	http://www.signallake.com/signallake.com/innovation/EdwardsScience062097.pdf
PubMed reference number	9188534v1
Volume Number	276
Issue Number	5320
Journal	Science
Language	English
Access Restriction	Open
Subject Keyword	Aerosol Dose Form Diameter (qualifier value) Drug Delivery Systems Glucose Inspiration function Kilogram per Liter Less Than Lung Mass Density Mean Diameter New type Testosterone Therapeutic procedure centimeter gram milliliter
Content Type	Text
Resource Type	Article

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