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Uterine artery embolization for symptomatic fibroids: short-term versus mid-term changes in disease-specific symptoms, quality of life and magnetic resonance imaging results.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Scheurig, Christian Gauruder-Burmester, Annett Kluner, Claudia Kurzeja, Roberto Lembcke, Alexander Zimmermann, Elke Hamm, Bernd |
| Copyright Year | 2006 |
| Abstract | BACKGROUND Prospective study to evaluate changes in symptom severity, health-related quality of life (HRQOL) and uterine and leiomyoma volume after uterine artery embolization (UAE). METHODS Eighty-two women completed a validated uterine fibroid symptom and quality of life (UFS-QOL) questionnaire and underwent magnetic resonance imaging (MRI) before and 3-20 months after UAE. Primary outcome measures were changes in symptom severity and QOL at short-term follow-up [median 5 (range 3-7) months] and mid-term follow-up [median 14 (8-20) months]. Secondary outcome measures included the frequency of additional procedures to control persistent symptoms and changes in dominant fibroid volume (DFV) and uterine volume (UV). RESULTS Of 82 patients, 71 (86.6%) patients completed follow-up, 7 (8.5%) patients had a second procedure and 4 (4.9%) were lost to follow-up. Symptom severity scores decreased from a median of 43.75 to 21.88 (P < 0.001) in the short-term follow-up group and from a median of 43.75 to 9.38 (P < 0.001) in the mid-term follow-up group. QOL scores increased from a median of 56.90 to 87.93 (P < 0.001) and 66.81 to 96.12 (P < 0.001), respectively. During short-term follow-up, median UV decreased by 27% (95% CI 20.25-33.81, P < 0.001) and median DFV by 62% (95% CI 47.81-71.55, P < 0.001), whereas UV decreased by 36% (95% CI 23.34-55.02, P < 0.001) and DFV by 66% (95% CI 54.28-71.92, P < 0.001) for the mid-term follow-up group. A decrease in UV correlated with change in symptom severity (P < 0.005). CONCLUSIONS Women report significant improvements in fibroid-specific symptoms and QOL at short- and mid-term follow-ups after UAE. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/humrep/21/12/10.1093_humrep_del275/2/del275.pdf?Expires=1492387776&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q&Signature=X8ujigC~KCFH8vgacngav2xw-5JnC3vtD~nD0yn4scNx5WbBFbtphniPuvzVy-DE8C2L8NN2koPzB3wn3aIDAhp3LZ9XD6ZAG-2S~cJ38ljLsELHeNXfo0~Upn9Ce3RruYNKkzp3Ja0nqur0ar0nxhEpcvwsn9k92hR7qN5CMQBWhq0j98sqm0qCgys8~RbiVpLPjaK91Z~~2Z0G7-A7z4Qpdj~vxJnOSgQWNbfYILtY9q-KhRUEj8Pt3IP~czA9MC03lRhpm6axK5gCPPEmEjSjGV28cDbb4Pglm8LYj-rE3f9aEA63UWbYSZVmN4lbYkDQ4TSEAuA2R4zVfck8Tw__ |
| PubMed reference number | 16877371v1 |
| Volume Number | 21 |
| Issue Number | 12 |
| Journal | Human reproduction |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Fibroid Tumor Follow-Up Report Magnetic Resonance Imaging Malignant Fibrous Histiocytoma Neoplasm Metastasis Patients Structure of uterine artery Uterine Artery Embolization Uterine Corpus Carcinosarcoma Uterine Fibroids Uterus |
| Content Type | Text |
| Resource Type | Article |
