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Safety of solifenacin combined with tamsulosin hydrochloride oral controlled absorption system in men with lower urinary tract symptoms and bladder outlet obstruction: a urodynamic study
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kaplan, Steven A. Schneider, Tim Koltun, William D. He, Weizhong Compion, Gerhard Cummings, Jana |
| Copyright Year | 2011 |
| Abstract | Hypothesis / aims of study Lower urinary tract symptoms (LUTS) are common in men >45 years of age. Storage symptoms in such men may be related to co-existing detrusor overactivity or may be secondary to bladder outflow obstruction (BOO). Given the possible safety concerns of an antimuscarinic in obstructed patients, this safety study investigated the effect of a combination of the antimuscarinic, solifenacin succinate (SOLI) and tamsulosin hydrochloride oral controlled absorption system (TOCAS) on bladder function in men with LUTS and BOO. The primary objective of this study was to evaluate the non-inferiority of TOCAS 0.4 mg + SOLI 6 mg or TOCAS 0.4 mg + SOLI 9 mg, vs placebo via urodynamic variables. Secondary objectives included tolerability and safety of TOCAS + SOLI, and efficacy of the combination treatment vs placebo. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.ics.org/Abstracts/Publish/106/000419.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
