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Development of an Industrial Process Based on the Groebke–Blackburn–Bienaymé Multicomponent Reaction: Efficient Preparation of 3-Aminoimidazo[1,2-a]pyrazines
| Content Provider | Semantic Scholar |
|---|---|
| Author | Baenziger, Markus Dr Durantie, Estelle Mathes, Christian |
| Copyright Year | 2017 |
| Abstract | 3-Aminoimidazo[1,2-a]pyrazine is an important scaffold that is found in many drugs. This scaffold is rapidly accessible through a Groebke–Blackburn–Bienayme cyclisation starting from an aminopyrazine, an aldehyde and an isocyanide. A scale-up process of this multicomponent reaction has been achieved in high yield and with excellent purity. The scope and limitations of this process leading to various 3-aminoimidazo[1,2-a]pyrazines are disclosed. |
| Starting Page | 2266 |
| Ending Page | 2274 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| DOI | 10.1055/s-0036-1588130 |
| Alternate Webpage(s) | https://www.thieme-connect.com/products/ejournals/pdf/10.1055/s-0036-1588130.pdf |
| Alternate Webpage(s) | https://www.thieme.de/statics/dokumente/thieme/final/en/dokumente/tw_chemistry/s-0036-1588130.pdf |
| Alternate Webpage(s) | https://doi.org/10.1055/s-0036-1588130 |
| Volume Number | 49 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
