NDLI: Endothelin-1 stimulates human monocytes in vitro to release TNF-α , IL-1β and IL-6

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Endothelin-1 stimulates human monocytes in vitro to release TNF-α , IL-1β and IL-6

Content Provider	Semantic Scholar
Author	Sildnes, Trude Seljelid, Rolf
Copyright Year	1993
Abstract	Increased plasma- and tissue levels of endothelin-1 (ET-1) during inflammatory diseases, have suggested a role of ET-1 in the pathophysiology of inflammatory reactions. The authors have studied the effect of ET-1 on cytokine release from monocytes and monocyte-derived macrophages. ET-1 increased secretion of TNF-alpha, IL-1beta and IL-6 in a dose- and time-dependent manner. Optimal ET-1 concentration ranged from 0.01 to 1 nM. The maximal response was a 200 to 400% increase in cytokine release. A time-course study revealed that the pattern of cytokines induced by ET-1 was different in monocytes and macrophages, although an early increase in TNF-alpha was observed in both monocyte and macrophage supernatants. In conclusion, ET-1 stimulates monocytes and macrophages to release cytokines thereby demonstrating a potential role for ET-1 in regulation of inflammatory responses.
Starting Page	417
Ending Page	422
Page Count	6
File Format	PDF HTM / HTML
PubMed reference number	18475557v1
Volume Number	2
Journal	Mediators of inflammation
Language	English
Access Restriction	Open
Subject Keyword	Adrenergic alpha-Agonists Endothelin-1 Interleukin-1 beta Interleukin-6 Monocytes Pelvic Inflammatory Disease Tumor Necrosis Factor-alpha cytokine inflammatory response macrophage
Content Type	Text
Resource Type	Article

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