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Origin of lipid and cholesterol in experimental thromboatherosclerosis.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Friedman, Meyer Byers, Sanford O. George, S. M. St |
| Copyright Year | 1962 |
| Abstract | Recently we have described (1) the sequence of phenomena that followed the experimental placement of a thrombus in the aorta of a hypercholesterolemic rabbit. It was found that the thrombus invariably elicited a hyperplastic intimal response leading eventually to a plaque (see Color Figure 1) which in its lipid and tissue characteristics bore a striking resemblance to the human atherosclerotic plaque. Moreover, necrosis, liquefaction, and even calcification of the central portions of the plaque were commonly observed. The sudanophilia and also the excess accumulation of cholesterol occurring in these plaques first became detectable about 14 days after the induction of the thrombus itself. Although hundreds of sections of these plaques were examined before, during, and shortly after this 14-day period, the first accumulation of the lipid never was observed in the superficially located intimal tissue which was in closest contact with the luminal blood (i.e., the intimal tissue encircling the periphery of the thrombus). Invariably such lipid made its first appearance in the deeper areas of the new intimal tissue immediately adjacent to the underlying media. Indeed, not infrequently, the first appearance of lipid was detected in the inner portion of the media underlying the newly formed plaque. These observations clearly suggested to us that the excess lipid (and presumably its cholesterol congener) was not derived from luminal blood. Its accumulation, therefore, appeared to be due to its transport by blood vessels newly derived from the adventitia or to its excess production in situ in the newly forming |
| Starting Page | 1 |
| Ending Page | 4 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://dm5migu4zj3pb.cloudfront.net/manuscripts/104000/104540/JCI62104540.pdf |
| Alternate Webpage(s) | http://www.jci.org/articles/view/104540/pdf/render |
| PubMed reference number | 13895274v1 |
| Volume Number | 41 |
| Journal | The Journal of clinical investigation |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adventitia Aorta Blood Clot Blood Vessel Calcinosis Cholesterol Dental Plaque Hyperplasia Necrosis Phenobarbital Senile Plaques Thrombosis |
| Content Type | Text |
| Resource Type | Article |
