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Diagnose und Therapie von Pilzinfektionen und der Pneumozystis-Pneumonie bei Kindern und Jugendlichen mit neoplastischen Erkrankungen
| Content Provider | Semantic Scholar |
|---|---|
| Author | Groll, Andreas H. Ritter, Julia |
| Copyright Year | 2005 |
| Abstract | Invasive fungal infections are important causes of morbidity and mortality in pediatric cancer patients with hematological malignancies and following allogeneic hematopoietic stem cell transplantation. This article provides the recommendations of the Infectious Diseases Working Party of the German Society for Pediatric Infectious Diseases (DGPI) and the German Society for Pediatric Hematology/Oncology (GPOH) for diagnosis and treatment of fungal infections including Pneumocystis jiroveci. They are based on specific pediatric pharmacological and regulatory considerations and on the results of clinical trials, case series and expert opinions using the evidence criteria set forth by the Infectious Diseases Society of America (IDSA). Recommendations for the most frequent clinical entities are summarized here. Options for initial therapy of uncomplicated candidemia include deoxycholate amphotericin B (DAMB), fluconazole (FLC), liposomal amphotericin B (LAMB), the combination of DAMB plus FLC as well as voriconazole (VCZ) for patients >11years. For acute disseminated candidiasis, the combination of DAMB plus flucytosine is recommended. Indwelling central venous catheters serve as infectious nidus and should be removed whenever feasible. Firstline therapy for presumed or proven invasive Aspergillus infections in patients 12years and older is VCZ with DAMB and LAMB serving as alternatives. Choices for patients <12years of age are essentially limited to DAMB and LAMB. Due to the yet lacking evidence for enhanced antifungal efficacy and the ongoing dosage finding of caspofungin (CAS) in pediatric patients, combination therapies (LAMB plus CAS or VCZ plus CAS) should only be considered for fulminant or massive, life threatening inTherapie von Infektionen in der Kinderonkologie |
| Starting Page | 37 |
| Ending Page | 66 |
| Page Count | 30 |
| File Format | PDF HTM / HTML |
| DOI | 10.1055/s-2005-872501 |
| Volume Number | 217 |
| Alternate Webpage(s) | https://www.p-e-g.org/files/content/Arbeitsgruppen/Groll_und_Ritter_Klin_Padiatr_05.pdf |
| Alternate Webpage(s) | https://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2005-872501.pdf |
| Alternate Webpage(s) | https://www.thieme-connect.com/products/ejournals/pdf/10.1055/s-2005-872501.pdf |
| Alternate Webpage(s) | https://s3-eu-west-1.amazonaws.com/awarticles/16288352.pdf |
| Alternate Webpage(s) | https://doi.org/10.1055/s-2005-872501 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
