NDLI: Antibodies against Wnt receptor of muscle-specific tyrosine kinase in myasthenia gravis

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Antibodies against Wnt receptor of muscle-specific tyrosine kinase in myasthenia gravis

Content Provider	Semantic Scholar
Author	Takamori, Masaharu Nakamura, Tatsufumi Motomura, Masakatsu
Copyright Year	2013
Abstract	Muscle-specific tyrosine kinase (MuSK) antibodies are detected in a proportion of myasthenia gravis (MG) patients who are negative for acetylcholine receptor (AChR) antibodies and have prominent bulbar weakness and crises. In the MuSK ectodomains, the immunoglobulin-like 1 and 2 domains (Ig1/2) mediate the agrin-Lrp4-MuSK signaling and the cysteine-rich domain (CRD) mediates the Wnt-MuSK-Dishevelled signaling; both contribute to AChR clustering. Immunoblotting against recombinant proteins showed MuSK Ig1/2 antibodies in 33 anti-AChR-negative MG patients; 10 patients of them (30%) were additionally positive for MuSK CRD antibodies. The result suggests that MuSK antibodies have heterogeneity in their binding to functional domains of MuSK.
Starting Page	183
Ending Page	186
Page Count	4
File Format	PDF HTM / HTML
DOI	10.1016/j.jneuroim.2012.09.001
PubMed reference number	22999188
Journal	Medline
Volume Number	254
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0165572812002743
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0165572812002743?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/j.jneuroim.2012.09.001
Journal	Journal of Neuroimmunology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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