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Experience with obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist in patients with relapsed or refractory classical Hodgkin lymphoma.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Oki, Yasuhiro Copeland, Amanda Hagemeister, Fredrick B. Fayad, Luis E. Fanale, Michelle A. Romaguera, Jorge E. Younes, Anas |
| Copyright Year | 2012 |
| Abstract | To the editor: Bcl-2 overexpression is frequently observed in classic Hodgkin lymphoma (cHL)[1][1] and may confer poor prognosis.[2][2],[3][3] Obatoclax mesylate (GX15-070) is a small-molecule antagonist of the Bcl-2 family of proteins, which activates apoptosis in vitro and exhibits anti-tumor |
| File Format | PDF HTM / HTML |
| DOI | 10.1182/blood-2011-11-391037 |
| PubMed reference number | 22383790 |
| Journal | Medline |
| Volume Number | 119 |
| Issue Number | 9 |
| Alternate Webpage(s) | http://www.bloodjournal.org/content/bloodjournal/119/9/2171.full.pdf?sso-checked=true |
| Alternate Webpage(s) | https://doi.org/10.1182/blood-2011-11-391037 |
| Journal | Blood |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |