NDLI: Functional analysis of the phosphoprotein PII (glnB gene product) in the cyanobacterium Synechococcus sp. strain PCC 7942.

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Functional analysis of the phosphoprotein PII (glnB gene product) in the cyanobacterium Synechococcus sp. strain PCC 7942.

Content Provider	Semantic Scholar
Author	Forchhammer, Karl Marsac, Nicole Tandeau De
Copyright Year	1995
Abstract	The PII protein (glnB gene product) in the cyanobacterium Synechococcus sp. strain PCC 7942 signals the cellular N status by being phosphorylated or dephosphorylated at a seryl residue. Here we show that the PII-modifying system responds to the activity of ammonium assimilation via the glutamine synthase-glutamate synthase pathway and to the state of CO2 fixation. To identify possible functions of PII in this microorganism, a PII-deficient mutant was created and its general phenotype was characterized. The analysis shows that the PII protein interferes with the regulation of enzymes required for nitrogen assimilation, although ammonium repression is still detectable in the PII-deficient mutant. We suggest that the phosphorylation and dephosphorylation of PII are part of a complex signal transduction network involved in global nitrogen control in cyanobacteria. In this regulatory process, PII might be involved in mediating the tight coordination between carbon and nitrogen assimilation.
File Format	PDF HTM / HTML
DOI	10.1128/jb.177.8.2033-2040.1995
PubMed reference number	7721695
Journal	Medline
Volume Number	177
Issue Number	8
Alternate Webpage(s)	http://jb.asm.org/content/177/8/2033.full.pdf
Alternate Webpage(s)	https://doi.org/10.1128/jb.177.8.2033-2040.1995
Journal	Journal of bacteriology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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