NDLI: Vaccination with Mycobacterium bovis BCG strains Danish and Pasteur in white-tailed deer (Odocoileus virginianus) experimentally challenged with Mycobacterium bovis.

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Vaccination with Mycobacterium bovis BCG strains Danish and Pasteur in white-tailed deer (Odocoileus virginianus) experimentally challenged with Mycobacterium bovis.

Content Provider	Semantic Scholar
Author	Palmer, Mitchell V. Thacker, Tyler C. Waters, W. Ray
Copyright Year	2009
Abstract	Wildlife reservoirs of Mycobacterium bovis represent serious obstacles to the eradication of tuberculosis in domestic livestock and the cause for many faltering bovine tuberculosis eradication programmes. One approach in dealing with wildlife reservoirs of disease is to interrupt inter-species and intraspecies transmission through vaccination of deer or cattle. To evaluate the efficacy of BCG vaccination in white-tailed deer, 35 deer were assigned to one of three groups; one s.c. dose of 10(7) CFU of M. bovis BCG Pasteur (n = 12); 1 s.c. dose of 10(7) CFU of M. bovis BCG Danish (n = 11); or unvaccinated deer (n = 12). After vaccination, deer were inoculated intratonsilarly with virulent M. bovis. Lesion severity scores of the medial retropharyngeal lymph node, as well as all lymph nodes combined, were reduced in vaccinated deer compared to unvaccinated deer. BCG Danish vaccinated deer had no late stage granulomas characterized by coalescent caseonecrotic granulomas containing numerous acid-fast bacilli compared to BCG Pasteur vaccinated or unvaccinated deer where such lesions were present. Both BCG strains were isolated as late as 250 days after vaccination from deer that were vaccinated but not challenged. In white-tailed deer, BCG provides protection against challenge with virulent M. bovis. Issues related to vaccine persistence, safety and shedding remain to be further investigated.
File Format	PDF HTM / HTML
DOI	10.1111/j.1863-2378.2008.01198.x
PubMed reference number	19175569
Journal	Medline
Volume Number	56
Issue Number	5
Alternate Webpage(s)	http://digitalcommons.unl.edu/cgi/viewcontent.cgi?article=1081&context=michbovinetb
Alternate Webpage(s)	https://naldc.nal.usda.gov/download/30759/PDF
Alternate Webpage(s)	https://digitalcommons.unl.edu/cgi/viewcontent.cgi?article=1081&context=michbovinetb
Alternate Webpage(s)	https://doi.org/10.1111/j.1863-2378.2008.01198.x
Journal	Zoonoses and public health
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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