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Effect of adrenalectomy on membrane properties and synaptic potentials in rat dentate granule cells.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Joëls, Marian Stienstra, Curt Karten, Yashmin J. G. |
| Copyright Year | 2001 |
| Abstract | Adrenalectomy is known to accelerate both neurogenesis and cell death of granule cells located in the suprapyramidal blade of the rat dentate gyrus. Three days after adrenalectomy, some granule cells have already died by apoptosis while newly formed cells are not yet incorporated in the cell layer, resulting in a temporary loss of granule cells. Concomitantly, the field response to stimulation of perforant path afferents is reduced. While the temporary cell loss is likely to attenuate synaptic field responses, adrenalectomy-induced changes in properties of the surviving cells may also contribute to the reduction in field response amplitude. To address this possibility, we here investigated the membrane properties and synaptic responses of dentate granule cells, 3 days after adrenalectomy. We found that passive and most of the active membrane properties of granule cells in adrenalectomized rats were not significantly different from the cell properties in sham-operated controls. However, intracellularly recorded synaptic responses from surviving granule cells were markedly reduced after adrenalectomy. The N-methyl-D-aspartate (NMDA)- and the non-NMDA receptor-mediated components were reduced to a similar extent, suggesting that the attenuation of synaptic transmission after adrenalectomy could be partly of presynaptic origin. The data indicate that the earlier observed attenuation of synaptic field responses after adrenalectomy may be partly due to a diminished glutamatergic input to the dentate gyrus and not exclusively to a loss of granule cells participating in the synaptic circuit. |
| Starting Page | 699 |
| Ending Page | 707 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://jn.physiology.org/content/jn/85/2/699.full.pdf |
| PubMed reference number | 11160504v1 |
| Volume Number | 85 |
| Issue Number | 2 |
| Journal | Journal of neurophysiology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Apoptosis Aspartic Acid Cell Death Cessation of life N-Methyl-D-Aspartate Receptors N-Methylaspartate Neurogenesis Perforant Pathway Structure of dentate gyrus Synaptic Potentials Synaptic Transmission Tissue membrane |
| Content Type | Text |
| Resource Type | Article |
