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The Relationship of EGFR and VEGF mRNA Expression in Ovarian Carcinoma
| Content Provider | Semantic Scholar |
|---|---|
| Author | Chen, Aiping Yang, Ruirui Zhang, Hongling Song, Hui |
| Copyright Year | 2009 |
| Abstract | E-mail: 2008cocr@gmail.com Tel (Fax): 86-22-2352 2919 OBJECTIVE Epidermal growth factor receptor (EGFR) is dysregulated in many human malignancies and is a potential target for therapeutic intervention, but there is a major disagreement among researchers about both the frequency and possible clinical importance of EGFR overexpression in ovarian cancer. We investigated the expression and significance of the EGFR mRNA and vascular endothelial growth factor (VEGF) mRNA in ovarian carcinoma. METHODS Reverse transcription polymerase chain reaction (RT-PCR) was employed to determine the expression of EGFR mRNA and VEGF mRNA in 79 ovarian specimen (including 15 normal, 13 benign and 51 malignant, from 79 patients). The relationship between EGFR and VEGF expression was analyzed. RESULTS The positive rates of the expression of EGFR mRNA and VEGF mRNA were significantly higher in the patients with ovarian carcinoma than those in both the patients with benign ovarian tumors and in the normal controls. There was correlation between EGFR mRNA expression and clinical stages. The positive rate of the expression of EGFR mRNA in Stage IIIIV was higher than that in Stage I-II of ovarian carcinoma (P < 0.05). The expression of VEGF mRNA was correlated with the clinical stages and lymph node metastasis. The expression levels of VEGF mRNA in Stage III-IV and in the group with lymph node metastasis were signifi cantly higher than those in Stage I-II and in the group without lymph node metastasis, respectively (P < 0.05). The expression of EGFR mRNA was positively correlated with the expression of VEGF mRNA (r = 0.438, P < 0.05). CONCLUSION The expressions of EGFR mRNA and VEGF mRNA are positively correlated to the occurrence of ovarian carcinoma and its metastasis. The detection of EGFR and VEGF may be helpful for the targeted chemotherapy. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.cancerbiomed.org/index.php/cocr/article/download/186/174 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Anaplastic thyroid carcinoma Anatomic Node Benign Ovarian Neoplasm Biological specimen CDISC SEND Biospecimens Terminology Epithelial ovarian cancer Fax Growth Factor Receptors Malignant neoplasm of ovary Neoplasms Ovarian Carcinoma Patients Reverse Transcriptase Polymerase Chain Reaction Seventy Nine Transcription (software) lymph node metastases lymph nodes stage II bladder cancer |
| Content Type | Text |
| Resource Type | Article |
