Loading...
Please wait, while we are loading the content...
Effects of the Female Estrous Cycle on the Sexual Behaviors and Ultrasonic Vocalizations of Male C57BL/6 and Autistic BTBR T+ tf/J Mice
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kim, Hyopil Son, Junehee Yoo, H. B. Kim, Hakyoo Oh, Jihae Han, Daehee Hwang, Yoon Soo Kaang, Bong-Kiun |
| Copyright Year | 2016 |
| Abstract | A primary characteristic of autism, which is a neurodevelopmental disorder, is impaired social interaction and communication. Furthermore, patients with autism frequently show abnormal social recognition. In mouse models of autism, social recognition is usually assessed by examining same-sex social behavior using various tests, such as the three-chamber test. However, no studies have examined the ability of male mice with autism to recognize the estrous cycle of female partners. In this study, we investigated the sexual behaviors, especially mounting and ultrasonic vocal communication (USV), of BTBR T+ tf/J (BTBR) mice, which are used as a well-known mouse model of autism, when they encountered estrus or diestrus female mice. As expected, C57BL/6 mice mounted more female mice in the estrus stage compared with the diestrus stage. We found that BTBR mice also mounted more female mice in the estrus stage than female mice in the diestrus stage. Although the USV emission of male mice was not different between estrus and diestrus female mice in both strains, the mounting result implies that BTBR mice distinguish sexual receptivity of females. |
| Starting Page | 156 |
| Ending Page | 162 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://synapse.koreamed.org/Synapse/Data/PDFData/0142EN/en-25-156.pdf |
| PubMed reference number | 27574482v1 |
| Alternate Webpage(s) | https://doi.org/10.5607/en.2016.25.4.156 |
| DOI | 10.5607/en.2016.25.4.156 |
| Journal | Experimental neurobiology |
| Volume Number | 25 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Autistic Disorder BTBR Mouse Behavior C57BL/6 Mouse Estrous Cycle Estrus Neurodevelopmental Disorders Patients Phobia, Social Physiological Sexual Disorders Social Communication Disorder Ultrasonics (sound) Vocal Cord Paralysis |
| Content Type | Text |
| Resource Type | Article |
