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Quantitation and Radical Scavenging Activity Evaluation of Iridoids and Phenylethanoids from the Roots of Phlomis umbrosa (Turcz.) using DPPH Free Radical and DPPH-HPLC Methods, and their Cytotoxicity
| Content Provider | Semantic Scholar |
|---|---|
| Author | Nguyen, Duc Hung Zhao, Bing Tian Min, Byung Sun Song, Si Whan |
| Copyright Year | 2019 |
| Abstract | − The roots of Phlomis umbrosa (Turcz.) (Phlomidis Radix) have been traditionally used to treat cold, reduce swelling and staunch bleeding. Four iridoids (1 − 3 and 5) and six phenylethanoid derivatives (4, and 6 − 10) were isolated from the roots of P. umbrosa. A simple, sensitive, and reliable analytical HPLC/PDA method was developed, validated, and applied to determine 10 marker compounds in Phlomidis Radix. Furthermore, the isolates were evaluated for cytotoxic and anti-oxidant activities as well as DPPH-HPLC method. Among them, compounds 4 and 6 – 9 displayed potent anti-oxidant capacities using DPPH assay with IC50 values of 27.7 ± 2.4, 10.2 ± 1.1, 18.0 ± 0.8, 19.1 ± 0.3, and 19.9 ± 0.6 μM, and compounds 6, 8, and 9 displayed significant cytotoxic activity against HL-60 with IC50 values of 35.4 ± 3.1, 18.6 ± 2.0, and 42.9 ± 3.0 μM, respectively. |
| Starting Page | 122 |
| Ending Page | 129 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| DOI | 10.20307/nps.2019.25.2.122 |
| Volume Number | 25 |
| Alternate Webpage(s) | https://synapse.koreamed.org/pdf/10.20307/nps.2019.25.2.122 |
| Alternate Webpage(s) | https://doi.org/10.20307/nps.2019.25.2.122 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
