NDLI: Short-term fluoxetine treatment enhances baroreflex control of sympathetic nervous system activity after hindlimb unloading.

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Short-term fluoxetine treatment enhances baroreflex control of sympathetic nervous system activity after hindlimb unloading.

Content Provider	Semantic Scholar
Author	Moffitt, Julia A. Johnson, Alan Kim
Copyright Year	2004
Abstract	Data in humans indicate that individuals with orthostatic hypotension that are refractory to other traditional forms of therapy are responsive to selective serotonin reuptake inhibitor (SSRI) treatment. We tested the hypothesis that SSRI administration would help correct the attenuated baroreflex control of sympathetic nervous system activity in the hindlimb-unloaded (HU) rat model of cardiovascular deconditioning. An initial study was conducted to determine the time course of effects of fluoxetine (Flu) administration on baroreflex control of lumbar sympathetic nerve activity (LSNA) in conscious, chronically instrumented rats. Animals received either vehicle (Veh, sterile water) or 10 mg/kg Flu for 1, 4, or 16 days of treatment. Data indicate that while 1-day and 16-day Flu administration did not affect baroreflex function, baroreflex control of LSNA was enhanced after 4-day (short term) Flu administration. HU rats were then treated with Flu for 4 days and compared with HU rats receiving Veh and to casted control rats maintained in the normal posture that received either Veh or short-term Flu treatment. Similar to pilot data, short-term Flu treatment enhanced baroreflex control of LSNA in both HU rats and control rats. These data taken together indicate that baroreflex control of sympathetic nervous system activity is a possible mechanism responsible for the successful treatment of orthostatic intolerance with Flu.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://ajpregu.physiology.org/content/ajpregu/286/3/R584.full.pdf
PubMed reference number	14761868v1
Volume Number	286
Issue Number	3
Journal	American journal of physiology. Regulatory, integrative and comparative physiology
Language	English
Access Restriction	Open
Subject Keyword	Baroreflex Body position CNS disorder Cardiovascular Diseases Fluoxetine Hindlimb Suspension Infertility Lower Extremity Nervous system structure Serotonin Uptake Inhibitors Shy-Drager Syndrome Skeletal Unloading mg/kg
Content Type	Text
Resource Type	Article

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