NDLI: Increased PTP1B expression and phosphatase activity in colorectal cancer results in a more invasive phenotype and worse patient outcome

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Increased PTP1B expression and phosphatase activity in colorectal cancer results in a more invasive phenotype and worse patient outcome

Content Provider	Semantic Scholar
Author	Hoekstra, Elmer Das, Asha Mooppilmadham Swets, Marloes Cao, Wanlu Woude, C. Janneke Van Der Bruno, Marco J. Peppelenbosch, Maikel Petrus Kuppen, Peter J. K. Hagen, Timo L. M. Ten Fuhler, Gwenny Manel
Copyright Year	2016
Abstract	Cell signaling is dependent on the balance between phosphorylation of proteins by kinases and dephosphorylation by phosphatases. This balance if often disrupted in colorectal cancer (CRC), leading to increased cell proliferation and invasion. For many years research has focused on the role of kinases as potential oncogenes in cancer, while phosphatases were commonly assumed to be tumor suppressive. However, this dogma is currently changing as phosphatases have also been shown to induce cancer growth. One of these phosphatases is protein tyrosine phosphatase 1B (PTP1B). Here we report that the expression of PTP1B is increased in colorectal cancer as compared to normal tissue, and that the intrinsic enzymatic activity of the protein is also enhanced. This suggests a role for PTP1B phosphatase activity in CRC formation and progression. Furthermore, we found that increased PTP1B expression is correlated to a worse patient survival and is an independent prognostic marker for overall survival and disease free survival. Knocking down PTP1B in CRC cell lines results in a less invasive phenotype with lower adhesion, migration and proliferation capabilities. Together, these results suggest that inhibition of PTP1B activity is a promising new target in the treatment of colorectal cancer and the prevention of metastasis.
Starting Page	21922
Ending Page	21938
Page Count	17
File Format	PDF HTM / HTML
PubMed reference number	26942883v1
Alternate Webpage(s)	https://doi.org/10.18632/oncotarget.7829
DOI	10.18632/oncotarget.7829
Journal	Oncotarget
Volume Number	7
Language	English
Access Restriction	Open
Subject Keyword	Assumed Biological Markers Body tissue Cell Proliferation Colorectal Carcinoma Cultured Cell Line Neoplasms Non-Small Cell Lung Carcinoma Oncogenes Patients Phosphoric Monoester Hydrolases Protein Tyrosine Phosphatase Protein dephosphorylation phosphoric monoester hydrolase activity protein tyrosine phosphatase, non-receptor type 1
Content Type	Text
Resource Type	Article

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