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bi oph ] 2 9 M ar 2 01 8 Spatial cytoskeleton organization supports targeted intracellular transport
| Content Provider | Semantic Scholar |
|---|---|
| Author | Hafner, Anne E. Rieger, Heiko |
| Copyright Year | 2018 |
| Abstract | The efficiency of intracellular cargo transport from specific source to target locations is strongly dependent upon molecular motor-assisted motion along the cytoskeleton. Radial transport along microtubules and lateral transport along the filaments of the actin cortex underneath the cell membrane are characteristic for cells with a centrosome. The interplay between the specific cytoskeleton organization and the motor performance realizes a spatially inhomogeneous intermittent search strategy. In order to analyze the efficiency of such intracellular search strategies we formulate a random velocity model with intermittent arrest states. We evaluate efficiency in terms of mean first passage times for three different, frequently encountered intracellular transport tasks: i) the narrow escape problem, which emerges during cargo transport to a synapse or other specific region of the cell membrane, ii) the reaction problem, which considers the binding time of two particles within the cell, and iii) the reaction-escape problem, which arises when cargo must be released at a synapse only after pairing with another particle. Our results indicate that cells are able to realize efficient search strategies for various intracellular transport tasks economically through a spatial cytoskeleton organization that involves only a narrow actin cortex rather than a cell body filled with randomly oriented actin filaments. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://arxiv-export-lb.library.cornell.edu/pdf/1709.05133 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
