NDLI: Ischemia-Responsive Protein (irp94) Gene Expression in Neurons

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Ischemia-Responsive Protein (irp94) Gene Expression in Neurons

Content Provider	Semantic Scholar
Author	Kim, Seung-Whan Chung, Sung-Pil Kim, Seung-Ho Choi, Jong-Soon Kwon, Kisang Kwon, O-Yu
Copyright Year	2007
Abstract	An increased expression of the ischemia-responsive protein gene (irp94) was detected in a Mongolian gerbil brain after an ischemic injury, particularly in the cerebral cortex and hippocampus. In a rat phaeochromocytoma tumour cell line (PC12 cells), actinomycin D blocked the irp94 gene expression but cycloheximide did not. This indicates that irp94 gene expression is transcriptionally controlled. The half-life of irp94 mRNA was estimated to be approx. 5 h using 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole (DRB). In addition, irp94 expression was enhanced by either endoplasmic reticulum (ER)-stress-inducible drugs or protease inhibitors. This suggests that irp94 gene expression is strongly associated with the unfolded protein response (UPR) in neurons
Starting Page	592
Ending Page	596
Page Count	5
File Format	PDF HTM / HTML
DOI	10.1515/znc-2007-7-822
PubMed reference number	17913078
Journal	Medline
Volume Number	62
Alternate Webpage(s)	https://ir.ymlib.yonsei.ac.kr/bitstream/22282913/97576/1/T200700788.pdf
Alternate Webpage(s)	http://znaturforsch.com/ac/v62c/s62c0592.pdf
Alternate Webpage(s)	http://www.znaturforsch.com/ac/v62c/62c0592.pdf
Alternate Webpage(s)	https://doi.org/10.1515/znc-2007-7-822
Journal	Zeitschrift fur Naturforschung. C, Journal of biosciences
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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