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Relazione tra alterazioni ghiandolari ecograficamente rilevabili e rischio cardiovascolare in pazienti affetti da Sindrome di Sjögren primaria
| Content Provider | Semantic Scholar |
|---|---|
| Author | Batticciotto, Alberto |
| Copyright Year | 2015 |
| Abstract | Background: Current thinking is that systemic inflammation, elevated levels of inflammatory cytokines, and immune dysregulation, typical of the inflammatory autoimmune disease, could play a role in accelerated atherosclerosis. Very limited data are present in literature up to now about sub-clinical cardiovascular involvement in Sjogren’s syndrome. It was demonstrated that salivary glands ultrasound (US) score is strictly related to the histological inflammatory abnormalities. Objective. We investigated sub-clinical cardiovascular involvement in primary Sjogren’s syndrome (pSS) patients by means of ADMA, coronary flow reserve (CFR), intima-media thickness (cIMT) and pulse wave velocity (PWV). Furthermore, we performed salivary glands US in this pSS group and compared the validated US score with cardiovascular parameters. Methods. Fifty-three consecutive outpatients with pSS (7 males, 46 females; mean age 59.8 range 43-80 years; mean disease duration of 59,5 range 6-156 months) without classical cardiovascular risk factors and overt cardiovascular disease, and 22 age- and gender-matched controls were enrolled. RF-QIMT and RF-QAS technologies were used for IMT and PWV evaluation and Dipyridamole transthoracic stress echocardiography assessed CFR. We also investigated plasma ADMA levels, inflammatory markers and autoantibodies. My Lab 70 (Esaote, Florence, Italy) with linear probe ( 6-18 MHZ) was used to assess salivary glands US according to the scoring system published by Salaffi et Al. Results. Although within the normal range, CFR in pSS patients was lower than that of the controls (2,6 ± 0,23 Vs 3,2 ± 0,32 p < 0,0001), whereas PWV and ADMA levels were significantly higher (9,2 ± 1,8 m/s Vs 6,8 ± 0,9 m/s p <0,0001 and 0,76 ± 0,07 μM Vs 0,54 ± 0,05 μM p < 0,0001). Although QIMT values were not different in the two groups, the percentage of pSS patients with pathological values was higher ( 47/53 Vs 12/22 p =0,001). Salivary glands US score was related to the BMI (p= 0,001), CRP (p= 0,034) and ANA (p< 0,0001) plasma levels but not to the sub-clinical cardiovascular involvement index evaluated in this study (PWV r= -0,205 p= 0.140, Q-IMT r= 0,261 p= 0,06, CRF r= -0,194 p= 0,249, ADMA r=0,249 p= 0,075). Conclusion. Even if CFR values were normal, higher ADMA levels, PWV values and percentage of subjects with pathological Q-IMT with respect to an homogeneous control group suggest that pSS patients without classical cardiovascular risk factors have an early endothelial dysfunction and sub-clinical atherosclerosis. Salivary US score is not related to the sub-clinical cardiovascular involvement parameters evaluated in this study. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://paduaresearch.cab.unipd.it/7543/1/Batticciotto_Alberto_tesi.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
