Tails of histones in DNA double-strand break repair.

Content Provider	Semantic Scholar
Author	Bilsland, Elizabeth Downs, Jessica A.
Copyright Year	2005
Abstract	DNA double-strand breaks (DSBs) are, arguably, the most deleterious form of DNA damage. An increasing body of evidence points to the inaccurate or inefficient repair of DSBs as a key step in tumorigenesis. Therefore, it is of great importance to understand the processes by which DSBs are detected and repaired. Clearly, these events must take place in the context of chromatin in vivo, and recently, a great deal of progress has been made in understanding the dynamic and active role that histone proteins and chromatin modifying activities play in DNA DSB repair. Here, we briefly review some of the most common techniques in studying DNA DSB responses in vivo, and focus on the contributions of covalent modifications of core histone proteins to these DNA DSB responses.
Starting Page	057602
Ending Page	057602
Page Count	1
File Format	PDF HTM / HTML
PubMed reference number	15843385v1
Volume Number	20
Issue Number	3
Journal	Mutagenesis
Language	English
Access Restriction	Open
Subject Keyword	Carcinogenesis Cell Death Covalent Interaction DNA Breaks, Double-Stranded DNA Damage DNA Repair Double Strand Break Repair H2AX protein, human Histone Code Histones Mammals Neoplasms Occur (action) Seventy Nine
Content Type	Text
Resource Type	Article