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Design, synthesis, and evaluation of isoindolinone-hydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Lee, Shoukou Shinji, Chihiro Ogura, Kiyoshi Shimizu, Motomu Satoko Sato, Mayumi Yoshida, Minoru Hashimoto, Yuichi Miyachi, Hiroyuki |
| Copyright Year | 2007 |
| Abstract | We designed and synthesized hydroxamic acid derivatives bearing a 4-(3-pyridyl)phenyl group as a cap structure, and found that they exhibit potent histone deacetylase (HDAC) inhibitory activity. A representative compound, 17a, showed more potent growth-inhibitory activity against pancreatic cancer cells and greater upregulation of p21(WAF1/CIP1) expression than the clinically used HDAC inhibitor suberoylanilide hydroxamic acid (Zolinza). |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.riken.jp/SPD/ChemicalGeneticsLab/Jounal/Lee_S2007.pdf |
| PubMed reference number | 17588744v1 |
| Volume Number | 17 |
| Issue Number | 17 |
| Journal | Bioorganic & medicinal chemistry letters |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Histone Deacetylase Histones Hydroxamic Acids Mandibular left third molar abutment Pancreatic carcinoma Thioctic Acid Vorinostat Zolinza cancer cell |
| Content Type | Text |
| Resource Type | Article |