1114 Immunocytochemical localization of a neural chondroitin sulfate proteoglycan, neurocan, and its related molecules corresponding to the C-and N-terminal portions of neurocan in the cerebellum of the rat

Content Provider	Semantic Scholar
Author	Nishizuka, Masako Arai, Yasumasa Matsui, Fumiko Oohira, Atsuhiko
Copyright Year	1996
Abstract	Drebrin is an actin-binding protein mainly expressed in neurons. During the postnatal development, an embryonic type of drebrin is replaced by an adult type by alternative RNA splicing mechanisms. Adult type drebrin is localized in the spines and thought to play a role in the structure-based plasticity of synapses. We studied developmental changes in the expression of drebrin isoforms in rat brain and in primary cultured cortical neurons. The data demonstrated that conversion of drebrin isoforms occurs coincidentally with the formation of synapses both in viva and in vitro. This in vitro system provides a useful model system for studying the neuronal maturation or the formation of postsynaptic structure. We investigated the activity dependency of isoform composition of drebrin in vitro.
File Format	PDF HTM / HTML
DOI	10.1016/0168-0102(96)88877-8
Volume Number	25
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/0168010296888778
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/0168010296888778?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/0168-0102%2896%2988877-8
Journal	Neuroscience Research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article