NDLI: Janus effect of antifreeze proteins on ice nucleation.

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Janus effect of antifreeze proteins on ice nucleation.

Content Provider	Semantic Scholar
Author	Liu, Kangyong Wang, Chunlei Ma, Ji Yun Shi, Guosheng Yao, Xi Fang, Haiping Song, Yunheub Wang, Jianjun
Copyright Year	2016
Abstract	The mechanism of ice nucleation at the molecular level remains largely unknown. Nature endows antifreeze proteins (AFPs) with the unique capability of controlling ice formation. However, the effect of AFPs on ice nucleation has been under debate. Here we report the observation of both depression and promotion effects of AFPs on ice nucleation via selectively binding the ice-binding face (IBF) and the non-ice-binding face (NIBF) of AFPs to solid substrates. Freezing temperature and delay time assays show that ice nucleation is depressed with the NIBF exposed to liquid water, whereas ice nucleation is facilitated with the IBF exposed to liquid water. The generality of this Janus effect is verified by investigating three representative AFPs. Molecular dynamics simulation analysis shows that the Janus effect can be established by the distinct structures of the hydration layer around IBF and NIBF. Our work greatly enhances the understanding of the mechanism of AFPs at the molecular level and brings insights to the fundamentals of heterogeneous ice nucleation.
Starting Page	14739
Ending Page	14744
Page Count	6
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://chemistry.pnas.org/content/pnas/early/2016/12/06/1614379114.full.pdf
PubMed reference number	27930318v1
Alternate Webpage(s)	https://doi.org/10.1073/pnas.1614379114
DOI	10.1073/pnas.1614379114
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume Number	113
Issue Number	51
Language	English
Access Restriction	Open
Subject Keyword	Antifreeze Proteins Depressive disorder Ice
Content Type	Text
Resource Type	Article

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