NDLI: Cholecystokinin antagonist lorglumide reverses chronic haloperidol-induced effects on dopamine neurons

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Cholecystokinin antagonist lorglumide reverses chronic haloperidol-induced effects on dopamine neurons

Content Provider	Semantic Scholar
Author	Jiang, Lian Hai Richard, J. Kasser Rex, Y. Wang
Copyright Year	1988
Abstract	Intravenous administration of the cholecystokinin (CCK) antagonist lorglumide (LORG) reversed chronic haloperidol (CHAL)-induced depolarization inactivation (DI) of dopamine (DA) cells in both the A9 and A10 areas. Moreover, microinjection of LORG, but not naloxone, directly into the medial nucleus accumbens (mNAc) dose-dependently reversed CHAL-induced effect. LORG injected into other brain regions was without effect. These results suggest that CCK receptors in the mNAc form an important link for maintaining CHAL-induced DI of DA cells and that CCK is involved in the therapeutic action of antipsychotic drugs.
Starting Page	165
Ending Page	168
Page Count	4
File Format	PDF HTM / HTML
DOI	10.1016/0006-8993(88)90330-7
PubMed reference number	3208120
Journal	Medline
Volume Number	473
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/0006899388903307
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/0006899388903307?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/0006-8993%2888%2990330-7
Journal	Brain Research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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