NDLI: Nicotinic acetylcholine receptor activation reduces skeletal muscle inflammation of mdx mice

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Nicotinic acetylcholine receptor activation reduces skeletal muscle inflammation of mdx mice

Content Provider	Semantic Scholar
Author	Leite, Paulo Emílio Côrrea Lagrota-Candido, Jussara Moraes, Louise D'Elia, Livia Quirico-Santos, Thereza
Copyright Year	2010
Abstract	Mdx mice develop an inflammatory myopathy characterized at different ages by myonecrosis with scattered inflammatory infiltrates followed by muscular regeneration and later persistent fibrosis. This work aimed to verify the putative anti-inflammatory role of nicotinic acetylcholine receptor (nAChR) in the mdx muscular lesion. Mitigation of myonecrosis and decreased TNFα production were accompanied by increased numbers of F4/80 macrophages expressing nAChRα7. In vivo treatment with nicotine attenuated muscular inflammation characterized by reduced metalloprotease MMP-9 activity, TNFα and NFkB content and increased muscular regeneration. Our data indicate that nAChR activation influences local inflammatory responses in the muscular lesion of mdx mice.
Starting Page	44
Ending Page	51
Page Count	8
File Format	PDF HTM / HTML
DOI	10.1016/j.jneuroim.2010.06.005
PubMed reference number	20615555
Journal	Medline
Volume Number	227
Alternate Webpage(s)	http://www.distrofiamuscular.net/nicotinic_activation.pdf
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0165572810002602
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0165572810002602?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/j.jneuroim.2010.06.005
Journal	Journal of Neuroimmunology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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Selective activation of α7 nicotinic acetylcholine receptor (nAChRα7) inhibits muscular degeneration in mdx dystrophic mice

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