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High prevalence of cisplatin-induced ototoxicity in Cape Town, South Africa.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Whitehorn, Heather Sibanda, Mncengeli Lacerda, Miguel Spracklen, T. F. Ramma, Lebogang Dalvie, Sameera Ramesar, R. S. |
| Copyright Year | 2014 |
| Abstract | BACKGROUND Cisplatin is administered as the first-line treatment of soft-tissue cancers. It has a reported cure rate of up to 85%, but is associated with a high incidence of ototoxicity, characterised by irreversible bilateral hearing loss and affecting 23 - 50% of adults who receive the drug. OBJECTIVES To determine the incidence of cisplatin-induced ototoxicity at Groote Schuur Hospital (GSH), Cape Town, South Africa. METHODS retrospective cross-sectional study of cisplatin-receiving cancer patients attending GSH between January 2006 and August 2011. RESULTS A total of 377 patients were recorded as receiving cisplatin therapy during the study period. A 300% increase in new cisplatin-receiving patients receiving audiological monitoring was observed between 2006 and 2010. However, only patients with all clinical data as well as baseline and follow-up audiometric analyses were investigated. One hundred and seven such patients were identified, 55.1% of whom developed cisplatin-induced ototoxicity while receiving high-dose (> or = 60 mg/m2) cisplatin treatment. Higher cumulative cisplatin dosages were associated with development of significant hearing loss (p = 0.027). The odds of developing cisplatin-induced hearing loss were elevated for patients with head and neck tumours and lymphoma (p = 0.0465 and p = 0.0563, respectively) and were significantly lower for those with reproductive cancers (p = 0.0371). CONCLUSION Comprehensive audiological monitoring should be available for every patient during cisplatin treatment to minimise the development of disabling hearing loss. |
| File Format | PDF HTM / HTML |
| DOI | 10.7196/SAMJ.7389 |
| PubMed reference number | 25118554 |
| Journal | Medline |
| Volume Number | 104 |
| Issue Number | 4 |
| Alternate Webpage(s) | http://www.samj.org.za/index.php/samj/article/download/7389/5902 |
| Alternate Webpage(s) | https://www.ajol.info/index.php/samj/article/download/102672/92939 |
| Alternate Webpage(s) | http://www.scielo.org.za/pdf/samj/v104n4/22.pdf |
| Alternate Webpage(s) | https://doi.org/10.7196/SAMJ.7389 |
| Journal | South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
