NDLI: Liriodenine inhibits dopamine biosynthesis and L-DOPA-induced dopamine content in PC12 cells

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Liriodenine inhibits dopamine biosynthesis and L-DOPA-induced dopamine content in PC12 cells

Content Provider	Semantic Scholar
Author	Jin, Chun Mei Lee, Jaejoon Yang, Yoo Jung Kim, Young Kyoon Ryu, Shi Yong Lee, Myung Lae
Copyright Year	2007
Abstract	The inhibitory effects of liriodenine, an aporphine isoquinoline alkaloid, on dopamine biosynthesis and L-DOPA-induced dopamine content increases in PC12 cells were investigated. Treatment of PC12 cells with 5–10 μM liriodenine significantly decreased the intracellular dopamine content in a concentration-dependent manner (IC50 value, 8.4 μM). Liriodenine was not cytotoxic toward PC12 cells at concentrations up to 20 μM. Tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AADC) activities were inhibited by 10 μM liriodenine to 20–70% and 10–14% of control levels at 3–12 h, respectively; TH activity was more influenced than AADC activity. The levels of TH mRNA, intracellular cyclic AMP and basal Ca2+concentration were also decreased by 10 μM liriodenine. In addition, 10 μM liriodenine reduced L-DOPA (20–100 μM)-induced increases in dopamine content. However, 10 μM liriodenine resulted in a protective effect against L-DOPA (50–-100 μM)-induced cytotoxicity. These results suggest that liriodenine regulates dopamine biosynthesis by partially reducing TH activity and TH gene expression and has protective effects against L-DOPA-induced cytotoxicity in PC 12 cells.
Starting Page	984
Ending Page	990
Page Count	7
File Format	PDF HTM / HTML
DOI	10.1007/BF02993967
PubMed reference number	17879752
Journal	Medline
Volume Number	30
Alternate Webpage(s)	http://dric.sookmyung.ac.kr/image_lib1/arpr/3008/300812.pdf
Alternate Webpage(s)	https://doi.org/10.1007/BF02993967
Journal	Archives of pharmacal research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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