Anti-Cancer efficacy of Umbelliferone against Benzo(a)pyrene-induced Lung Carcinogenesis in Swiss Albino Mice

Content Provider	Semantic Scholar
Author	Salam, Sharmila Velli, Sathesh Kanna Krishnan, Palanisamy Selvanathan, Indumathi Murugan, Manikandan Subramaniam, Nirmala Thiruvengadam, Devaki
Copyright Year	2018
Abstract	Coumarins and coumarin-related compound are a plentiful source of latent drugs candidate in relation to its protection and effectiveness. The recent study was deliberate to observe the therapeutic result of Umbelliferone (UMB) against Benzo(a)Pyrene induced carcinogenesis in Swiss albino mice. Administration of B(a)P to mice caused in augmented relative lung weight and serum marker enzymes (AHH ,λ-GT and LDH). The levels of lipid peroxides important (in both serum and tissue) with a subsequent reduction in the final body weight and tissue antioxidants like (SOD, CAT, GPx, GR and GST non enzymic antioxidants (GSH, vitamin C, vitamin E and vitamin A).UMB supplementation knowingly reduced these alterations, thereby showing prevailing anticancer effect in lung cancer. Histology examination also clearly showed that UMB significantly inhibited the lung carcinogenesis induced by B(a)P. Based on the results, this study clearly indicates the UMB used as an effective compound against lung carcinogenesis induced by B(a)P.
Starting Page	79
Ending Page	89
Page Count	11
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.malayabiosciences.com/articles/5._Sharmila_MJB_2018_5(2)_79-89.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article