NDLI: Cystatin C: A Better Predictor of Kidney Function in Diabetic Patients

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Cystatin C: A Better Predictor of Kidney Function in Diabetic Patients

Content Provider	Semantic Scholar
Author	Shima, Ts Khatun, Ayesha Yeasmin, Farida Ferdousi, Sultana Kirtania, Kalyan Sultana, Nayma
Copyright Year	2013
Abstract	Serum cystatin C is a new promising marker of renal function. The aim of this study was to analyze serum cystatin C as a better predictor of renal function in diabetic nephropathy. In 60 diagnosed diabetic patients, serum cystatin C and serum creatinine were assessed. Glomerular filtration rate was estimated based on the cystatin C concentration according to Cockcroft- Gault formula and based on serum creatinine concentration according to Larsson formula. DTPA-GFR (Diethylenetriamene pentaacetate Renogram) was done as reference standard. The cross tabulation of DTPA-GFR was done with eGFR- creatinine and eGFRcystatin C. The calculated sensitivity, specificity and accuracy of eGFR- creatinine were 85%, 87.2% and 85% respectively. The eGFR- cystatin C showed higher sensitivity, specificity and accuracy than eGFR- creatinine in studied diabetic subjects. The cystatin C showed more significant correlation, r=0.78, p<0.001 than serum creatinine, r=0.59, p<0.001 with DTPA-GFR in diabetic patients. This study demonstrates that serum cystatin C may be used for early prediction for renal function impairment in diabetic kidney disease. DOI: http://dx.doi.org/10.3329/bjmb.v4i1.13777 Bangladesh J Med Biochem 2011; 4(1): 16-20
Starting Page	16
Ending Page	20
Page Count	5
File Format	PDF HTM / HTML
Volume Number	4
Alternate Webpage(s)	https://www.banglajol.info/index.php/BJMB/article/download/13777/9898
Alternate Webpage(s)	https://doi.org/10.3329/bjmb.v4i1.13777
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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