NDLI: The Correlation between Macular Ischemia by Fundus Fluorescein Angiography and Spectral Domain Optical Coherence Tomography Findings in Diabetic Macular Edema

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The Correlation between Macular Ischemia by Fundus Fluorescein Angiography and Spectral Domain Optical Coherence Tomography Findings in Diabetic Macular Edema

Content Provider	Semantic Scholar
Author	Dahab, Dina T. Abdel-Salam Ahmed Raafat, Adel Fathy Karim
Copyright Year	2018
Abstract	Background: To study the association between the OCT structural changes, and vascular changes around the fovea in FFA in the detection of ischemic diabetic maculopathy. Material and Methods: A 35 eyes of 25 patients with ischemic and mixed diabetic maculopathy were included as determined by irregular margins of the FAZ in fluorescein angiography. We measured the best-corrected visual acuity (BCVA), central macular thickness, inner retinal layer thickness and the lateral extent of inner segment-outer segment (ISOS) disruption on SD-OCT images, as well as the FAZ to optic nerve head (FAZ/ONH) area ratio using the Image J program. Results: The central macular thickness and the inner retinal layer thickness showed no significant correlation with FAZ/ONH area ratio (p=0.161, 0.480 respectively). The mean horizontal and vertical extents of IS-OS disruption were not significantly correlated with FAZ/ONH area ratio (p=0.630 and p=0.732 respectively. The horizontal and vertical extents of IS-OS disruption showed a significant correlation with Log MAR BCVA (r=0.798 and 0.795 respectively, p<0.001 in both). The FAZ/ONH area ratio was positively correlated with LogMAR BCVA but was not statistically significant ( p=0.815, r=–0.041). Conclusion: In patients with diabetic retinopathy, it is not possible to predict FAZ area based solely on the measurements assessing volume and thickness or retinal structure evaluation on OCT. Consequently, at present OCT cannot replace FA in the detection of ischemic or mixed diabetic maculopathy.
Starting Page	1213
Ending Page	1219
Page Count	7
File Format	PDF HTM / HTML
DOI	10.21608/mjcu.2018.56275
Volume Number	86
Alternate Webpage(s)	http://journals.ekb.eg/article_56275_736f918fd7205ddbe0d2f7f076f7eac6.pdf
Alternate Webpage(s)	https://doi.org/10.21608/mjcu.2018.56275
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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