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Hypertension sustains plaque progression despite reduction of hypercholesterolemia.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Xu, Cheng P. Glagov, Seymour |
| Copyright Year | 1991 |
| Abstract | To assess the effect of hypertension on diet-induced coronary artery plaques after a return to a nonatherogenic diet, 10 cynomolgus monkeys were fed an induction regimen containing 2% cholesterol and 25% peanut oil for 6 months and then were subjected to midthoracic aortic coarctation to induce hypertension. The animals were then fed a nonatherogenic "prudent" ration for 6 additional months (hypertension-regression group). Twelve additional monkeys were fed the atherogenic diet for 6 months; six were killed (lesion-induction control group) and six were changed to the prudent diet for 6 additional months without coarctation (normotension-regression control group). At the end of the induction period, cholesterol levels averaged 744 +/- 178 mg/dl for the 22 animals and were similar for the three groups throughout the induction period. For the animals restored to the nonatherogenic diet (hypertension-regression and normotension-regression groups), serum cholesterol levels fell to 486 +/- 252 mg/dl at 1 month, to 341 +/- 162 mg/dl at 2 months, and to 234 +/- 78 mg/dl at 6 months. There was no significant difference between the hypertensive and normotensive animals. Six months after coarctation, blood pressure proximal to the coarctations for the hypertension-regression group ranged from 100/60 to 220/145 mm Hg with a mean of 166/103 +/- 36/28 mm Hg. Cross-sectional area of coronary plaques was somewhat lower for the normotension-regression control group compared with the lesion-induction control group, but the difference was not significant. Plaque area was, however, markedly greater in the hypertension-regression group than in either the lesion-induction or the normotension-regression groups (p less than 0.05 for each) despite progressive reduction in hyperlipidemia.(ABSTRACT TRUNCATED AT 250 WORDS) |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://hyper.ahajournals.org/content/hypertensionaha/18/2/123.full.pdf?download=true |
| Alternate Webpage(s) | http://hyper.ahajournals.org/content/hypertensionaha/18/2/123.full.pdf |
| PubMed reference number | 1885220v1 |
| Volume Number | 18 |
| Issue Number | 2 |
| Journal | Hypertension |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Aortic Valve Stenosis Aortic coarctation Cholesterol Coronary Artery Disease Dental Plaque Diet, Atherogenic Hematological Disease Hypercholesterolemia Hypertensive disease Macaca fascicularis Mercury Monkeys Senile Plaques arachis oil mg/dl |
| Content Type | Text |
| Resource Type | Article |
