NDLI: Citrus aurantium (bitter orange) seeds oil: pharmacognostic, anti-inflammatory and anti-nociceptive properties

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Citrus aurantium (bitter orange) seeds oil: pharmacognostic, anti-inflammatory and anti-nociceptive properties

Content Provider	Semantic Scholar
Author	Hamedi, Azadeh Zarshenas, Mohammad M. Jamshidzadeh, Akram Ahmadi, Saeed Heidari, Reza Pasdaran, Ardalan
Copyright Year	2019
Abstract	The present investigation was carried out to evaluate the pharmacognostic properties of Citrus aurantium seeds as well as its anti-inflammatory activities. The n-hexane fraction of seed oil extracted via a Soxhlet extractor and subjected to pharmacognostic assays, HPTLC and GC-MS analysis for determination of fatty acids and sterols. The possible anti-inflammatory and antinociceptive activities in rats were evaluated using formalin-induced paw licking, oedema and myeloperoxidase activity assessment. Total ash, acid insoluble and water soluble ash values were determined as 35.83 ± 4.92, 6.67 ± 2.89 and 28.33 ± 5.77 mg/g, respectively. HPTLC assessment revealed the presence of different fatty acids and steroidal triterpenes. The principal fatty acids of the seed oil were linoleic acid (C18:2, 50.10 ± 2.58 %) and Oleic acid (C18:1, 30.14 ± 0.39). Esterified (2.40 mg/g) and free β-sitosterol (32.90 mg/g), free campesterol (3.9 mg/g) and free stigmasterol (10.165 mg/g) were detected in the oil. Seed oil exhibited anti-inflammatory properties in the first and the second phases of formalin test. Also, it had anti-edematogenic effects but exerted no effects on myeloperoxidase activity.
Starting Page	153
Ending Page	164
Page Count	12
File Format	PDF HTM / HTML
DOI	10.30476/tips.2019.82996.1020
Volume Number	5
Alternate Webpage(s)	http://tips.sums.ac.ir/article_45604_a8d6e088946aab7c8de51f36ac164110.pdf
Alternate Webpage(s)	https://doi.org/10.30476/tips.2019.82996.1020
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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