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Beta estrogen receptor knockout (BERKO) mice present attenuated hippocampal CA1 long-term potentiation and related memory deficits in contextual fear conditioning
| Content Provider | Semantic Scholar |
|---|---|
| Author | Day, Mark Sung, Amy Logue, Sheree Bowlby, Mark Arias, Robert |
| Copyright Year | 2005 |
| Abstract | Estrogen has marked effects on hippocampal synaptic plasticity. We demonstrate that male and female 3-month-old beta estrogen receptor knockout (BERKO) mice show profound memory impairment in a hippocampus-mediated fear-conditioning paradigm. Subsequently, hippocampal slices prepared from behaviorally naive female BERKO mice were examined electrophysiologically. These were found to have robust synaptic deficits, compared to slices from age-matched wild type controls, both in terms of their input-output curves and their expression of long-term-potentiation in area CA1. This report provides the first concrete evidence of significant hippocampal synaptic plasticity and memory deficits in the BERKO mouse. |
| Starting Page | 128 |
| Ending Page | 131 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.bbr.2005.05.011 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0166432805002354 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0166432805002354?dgcid=api_sd_search-api-endpoint |
| PubMed reference number | 16054246 |
| Alternate Webpage(s) | https://doi.org/10.1016/j.bbr.2005.05.011 |
| Journal | Medline |
| Volume Number | 164 |
| Journal | Behavioural Brain Research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |