Loading...
Please wait, while we are loading the content...
Similar Documents
Treatment of blastic phase chronic myeloid leukemia with mitoxantrone, cytosine arabinoside and high dose methylprednisolone.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Bolaman, Zahit Koeseoglu, Mehmet Ayyildiz, Orhan Kadiköylü, Gürhan Sönmez, Hulki Meltem Demir, Süleyman Cansun Müftüoğlu, Ekrem |
| Copyright Year | 2002 |
| Abstract | Fourteen patients with blastic phase chronic myelogenous leukemia received combination chemotherapy with mitoxantrone 5 mg/m2 intravenously daily for 3 days, cytosine arabinoside 100 mg/m2 intravenously over 2 hours bid for 7 days and high dose methylprednisolone 1000 mg/day intravenously for 5 days. The patients' mean age was 52 +/- 10 (range 34-64) and Philadelphia chromosome was positive in all. Five patients (35%) achieved complete remission and four patients (28%) had a partial remission. Overall remission rate was 64%. The mean survival was 11.1 +/- 8.6 months (median 13) for all patients, 19.4 +/- 4.0 months (median 19) for those achieving a complete remission, 12.50 +/- 5.7 months (median 14) for patients with partial remission and 1.8 +/- 1.8 months (median 2) for the unresponsive patients. Two of 5 unresponsive patients died early after the second course of remission induction. The treatment regimen was generally well tolerated. Marrow hypoplasia was observed in 9 (64%) patients and 7 (50%) had febrile episodes. Non-myelosupressive toxicity of the regimen was acceptable. Nausea and vomiting were observed in 8 (57%) patients and 3 (21%) patients developed flushing due to cytosine arabinoside. These results suggest that the regimen with mitoxantrone, cytosine arabinoside and high dose methylprednisolone in remission-induction of blastic phase chronic myelogenous leukemia may be a valid option that may also improve overall prognosis. |
| Starting Page | 49 |
| Ending Page | 57 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.hem-aids.ru/system/files/%252Fwww/hemaids/www/htdocs/files/Methypred+in+CML.pdf |
| PubMed reference number | 12243555v1 |
| Volume Number | 32 |
| Issue Number | 1 |
| Journal | Haematologia |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adverse reaction to drug Blast Phase Bone Marrow Transplantation Cessation of life Congenital chromosomal disease Cytarabine Cytosine Fever Flushing Forecast of outcome Hypoplasia Leukemia, B-Cell Methylprednisolone Milligram per Square Meter Mitoxantrone Myeloid Leukemia Myeloid Leukemia, Chronic Nausea One Thousand Patients Vomiting |
| Content Type | Text |
| Resource Type | Article |
