Inhibitory Effects of Swietenia Mahagoni Seeds Extract on Α-Glucosidase and Α-amylase

Content Provider	Semantic Scholar
Author	Bakeri, Nor Asyiqin Zahari, Mohd Amzar Mohamed Kamarulzaman, F. N. Mohd Yusof, Nuraqilah Mustafa, Nik Musaadah Salleh, Liza Md Norodin, Nur Salsabila Md
Copyright Year	2018
Abstract	This study analyzed the inhibition activity of Swietenia mahagoni seeds extract on α-glucosidase and α-amylase enzymes inhibition assays. Swietenia mahagoni seeds were extracted by using Supercritical Carbon Dioxide (SC-CO2) extraction at pressures of 20- 30 MPa and temperatures of 40- 60°C. The oil yields obtained were analyzed with α- glucosidase and α- amylase enzymes inhibition assays. All data obtained were expressed as mean ± standard deviation for triplicate experiments. One way analysis was used for statistical significance by using Statistica software version 7.0 (StartSoft, EUA) and IC50 (extract concentration causing 50% enzyme inhibitory) was determined by using GraphPad Prism 6.0 software. Swietenia mahagoni seeds extract have a strong inhibition of α-glucosidase enzyme activity (98.4% ± 0.2) but a moderate inhibition of α- amylase enzyme activity (34.9% ± 1.2). These findings implied that Swietenia mahagoni seeds extract could be an effective natural antidiabetic agent.
Starting Page	1308
Ending Page	1317
Page Count	10
File Format	PDF HTM / HTML
DOI	10.5829/ije.2018.31.08b.20
Volume Number	31
Alternate Webpage(s)	http://www.ije.ir/article_73249_5b75c9ebc188c87fa8900513ae08929b.pdf
Alternate Webpage(s)	https://doi.org/10.5829/ije.2018.31.08b.20
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article