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Processing of global, but not local, motion direction is deficient in schizophrenia
| Content Provider | Semantic Scholar |
|---|---|
| Author | Chen, Yue Nakayama, Kimiko Levy, Deborah L. Matthysse, Steven Holzman, Philip S. |
| Copyright Year | 2003 |
| Abstract | Visual motion processing is compromised in a substantial proportion of schizophrenic patients, but precise neural mechanisms underlying the motion-processing deficit have not yet been elaborated. The visual motion pathway includes a local and a global processing stage, each of which has distinct neural substrates. Here, we attempt to identify the stage(s) that are implicated in impaired motion processing of schizophrenia-local, global, or both. For schizophrenia patients (n=23) and normal controls (n=26), we measured (1) the thresholds for detecting the motion direction of a random dot pattern, a task that requires global motion processing, and (2) the thresholds for detecting the motion direction of a grating, a task that requires only local motion processing, using psychophysical methods. Schizophrenia patients showed elevated thresholds for detecting the direction of coherent motion, particularly for the high dot-density target. In contrast, schizophrenia patients showed normal thresholds for detecting the direction of motion of a grating. The results indicate that the global, but not the local, processing stage of the visual motion system is compromised in schizophrenia patients, thus implicating motion-sensitive brain areas that possess large receptive fields for spatial and temporal integration, such as Middle Temporal Area/Medial Superior Temporal Area. |
| Starting Page | 215 |
| Ending Page | 227 |
| Page Count | 13 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/S0920-9964(02)00222-0 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0920996402002220 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0920996402002220?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | http://visionlab.harvard.edu/members/ken/Papers/122schizoresearchChen.pdf |
| PubMed reference number | 12729873 |
| Alternate Webpage(s) | https://doi.org/10.1016/S0920-9964%2802%2900222-0 |
| Journal | Medline |
| Volume Number | 61 |
| Journal | Schizophrenia Research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
