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L-Proline as an efficient catalyst for synthesis of N-heterocyclic chalcones as potential antibacterial agents
| Content Provider | Semantic Scholar |
|---|---|
| Author | Bhupathi, Raja Sekhar Devi, Bhoomireddy Rama Dubey, Pramod Kumar |
| Copyright Year | 2012 |
| Abstract | The condensation of 4-hydroxy-3-acetyl-1H-quinoline-2-one 1 and substitutedbenzaldehydes 2a-i in DMSO solution at room temperature yields quinolone chalcone derivatives 3a-i. L-Proline has been found to be an efficient catalyst for this condensation between 1 and 2. Only 5 mol% of the catalyst is necessary to achieve good yields of the products. Reactions proceed smoothly with variations of the substituents. 1 itself is synthesized by the acylation of commercially available methyl anthranilate 4 with acetoacetic ester 5 in refluxing xylene and subsequent Dieckman intramolcular cyclization of the intermediary 2-methoxycarbonylanilide 6. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://nopr.niscair.res.in/bitstream/123456789/14232/1/IJCB%2051B(6)%20855-859.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
