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Self-assembly of amphiphilic tripeptides with sequence-dependent nanostructure.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Sahoo, Jugal Kishore Nazareth, Calvin Berg, Michael A. Vanden Webber, Matthew J. |
| Copyright Year | 2017 |
| Abstract | Supramolecular chemistry enables the creation of a diversity of nanostructures and materials. Many of these have been explored for applications as biomaterials and therapeutics. Among them, self-assembling peptides have been broadly applied. The structural diversity afforded from the library of amino acid building blocks has enabled control of emergent properties across length-scales. Here, we report on a family of amphiphilic tripeptides with sequence-controlled nanostructure. By altering one amino acid in these peptides, we can produce a diversity of nanostructures with different aspect-ratio and geometry. Peptides that produce high aspect-ratio structures can physically entangle to form hydrogels, which support cell viability in culture. Importantly, in comparison to many other short self-assembling peptide biomaterials, those reported here form filamentous nanostructures in the absence of typical secondary structures (i.e., β-sheet). Thus, we have illustrated a facile way to obtain versatile biomaterials with different nanostructural morphology from short and defined peptide sequences. |
| Starting Page | 1526 |
| Ending Page | 1530 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.1039/c7bm00304h |
| Alternate Webpage(s) | http://www.rsc.org/suppdata/c7/bm/c7bm00304h/c7bm00304h1.pdf |
| PubMed reference number | 28518205 |
| Alternate Webpage(s) | https://doi.org/10.1039/c7bm00304h |
| Journal | Medline |
| Volume Number | 5 |
| Issue Number | 8 |
| Journal | Biomaterials science |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
