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Studies of cardiopulmonary blood volume. Measurement of left ventricular volume by dye dilution.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Levinson, G. E. Nadimi, M. |
| Copyright Year | 1967 |
| Abstract | The measurement of ventricular end-diastolic volume from washout of an indicator requiring blood sampling was studied in a heart model and in dogs and applied to the left ventricle in 34 human subjects. The model, under the ideal conditions of constant ejection fraction, uniform cycle length, and complete or nearly complete mixing, demonstrated that dye dilution accurately measures chamber volumes if the distorting effects of catheter sampling are obviated by clearance of the sampling system at least once per two cardiac cycles. The studies in dogs and in human beings demonstrated that the required sampling conditions are achievable. In 11 normal human subjects, left ventricular end-diastolic volume ranged from 72 to 99 with a mean of 82 + 12 mI/M,2 end-systolic volume, from 22 to 60 with a mean of 37 + 11 ml/m,2 and ejection fraction, from 0.39 to 0.71 with a mean of 0.55 0.08. These measurements are in substantial agreement with results by radiocardiography and thermal dilution and are systematically, but only slightly, higher than results by quantitative angiocardiography. In six considerably older patients with chronic pulmonary disease, cardiac output was normal for the age group but ejection from a ventricle of normal size was reduced. In 12 subjects with pure mitral stenosis and in five with atrial septal defect, end-diastolic volume and ejection fraction were significantly reduced. End-diastolic volume correlated with stroke volume in all groups and in the series as |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://circ.ahajournals.org/content/circulationaha/35/6/1038.full.pdf |
| PubMed reference number | 5338121v1 |
| Volume Number | 35 |
| Issue Number | 6 |
| Journal | Circulation |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Angiocardiography Atrial Septal Defects Blood Volume Canis familiaris Cardiac Output Cardiopulmonary Cerebrovascular accident Chronic Obstructive Airway Disease Diastole Dyes Ejection fraction (procedure) Heart Atrium Heart Diseases Heart Septal Defects Heart Ventricle Left ventricular structure Lung diseases Mitral Valve Stenosis Ninety Nine Patients Premature ventricular contractions Sampling - Surgical action Stroke Volume Venous blood sampling radiocardiography |
| Content Type | Text |
| Resource Type | Article |
